Ontology highlight
ABSTRACT:
SUBMITTER: Minagawa K
PROVIDER: S-EPMC4491658 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Minagawa Kentaro K Zhou Xiaoou X Mineishi Shin S Di Stasi Antonio A
Pharmaceuticals (Basel, Switzerland) 20150508 2
T-cells genetically redirected with a chimeric antigen receptor (CAR) to recognize tumor antigens and kill tumor cells have been infused in several phase 1 clinical trials with success. Due to safety concerns related to on-target/off-tumor effects or cytokine release syndrome, however, strategies to prevent or abate serious adverse events are required. Pharmacologic therapies; suicide genes; or novel strategies to limit the cytotoxic effect only to malignant cells are under active investigations ...[more]