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Seatbelts in CAR therapy: How Safe Are CARS?

ABSTRACT: T-cells genetically redirected with a chimeric antigen receptor (CAR) to recognize tumor antigens and kill tumor cells have been infused in several phase 1 clinical trials with success. Due to safety concerns related to on-target/off-tumor effects or cytokine release syndrome, however, strategies to prevent or abate serious adverse events are required. Pharmacologic therapies; suicide genes; or novel strategies to limit the cytotoxic effect only to malignant cells are under active investigations. In this review, we summarize results and toxicities of investigations employing CAR redirected T-cells, with a focus on published strategies to grant safety of this promising cellular application.

SUBMITTER: Minagawa K

PROVIDER: S-EPMC4491658 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature

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Seatbelts in CAR therapy: How Safe Are CARS?

Minagawa Kentaro K Zhou Xiaoou X Mineishi Shin S Di Stasi Antonio A

Pharmaceuticals (Basel, Switzerland) 20150508 2

T-cells genetically redirected with a chimeric antigen receptor (CAR) to recognize tumor antigens and kill tumor cells have been infused in several phase 1 clinical trials with success. Due to safety concerns related to on-target/off-tumor effects or cytokine release syndrome, however, strategies to prevent or abate serious adverse events are required. Pharmacologic therapies; suicide genes; or novel strategies to limit the cytotoxic effect only to malignant cells are under active investigations ...[more]

PMID: 26110321

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