CAR-T Cell Therapy for Lymphoma.
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ABSTRACT:
SUBMITTER: Ramos CA
PROVIDER: S-EPMC4732525 | biostudies-other | 2016
REPOSITORIES: biostudies-other
Publications
CAR-T Cell Therapy for Lymphoma.
Ramos Carlos A CA Heslop Helen E HE Brenner Malcolm K MK
Annual review of medicine 20150826
Lymphomas arise from clonal expansions of B, T, or NK cells at different stages of differentiation. Because they occur in the immunocyte-rich lymphoid tissues, they are easily accessible to antibodies and cell-based immunotherapy. Expressing chimeric antigen receptors (CARs) on T cells is a means of combining the antigen-binding site of a monoclonal antibody with the activating machinery of a T cell, enabling antigen recognition independent of major histocompatibility complex restriction, while ...[more]
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