The role of intracellular calcium for the development and treatment of neuroblastoma.
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ABSTRACT:
SUBMITTER: Satheesh NJ
PROVIDER: S-EPMC4491686 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Publications
The role of intracellular calcium for the development and treatment of neuroblastoma.
Satheesh Noothan Jyothi NJ Büsselberg Dietrich D
Cancers 20150522 2
Neuroblastoma is the second most common paediatric cancer. It developsfrom undifferentiated simpatico-adrenal lineage cells and is mostly sporadic; however, theaetiology behind the development of neuroblastoma is still not fully understood. Intracellularcalcium ([Ca2+]i) is a secondary messenger which regulates numerous cellular processesand, therefore, its concentration is tightly regulated. This review focuses on the role of[Ca2+]i in differentiation, apoptosis and proliferation in neuroblasto ...[more]
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