Ontology highlight
ABSTRACT:
SUBMITTER: Hernandez-Ochoa EO
PROVIDER: S-EPMC4709859 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Frontiers in physiology 20160112
The skeletal muscle Ca(2+) release channel, also known as ryanodine receptor type 1 (RyR1), is the largest ion channel protein known and is crucial for effective skeletal muscle contractile activation. RyR1 function is controlled by Cav1.1, a voltage gated Ca(2+) channel that works mainly as a voltage sensor for RyR1 activity during skeletal muscle contraction and is also fine-tuned by Ca(2+), several intracellular compounds (e.g., ATP), and modulatory proteins (e.g., calmodulin). Dominant and r ...[more]