Ontology highlight
ABSTRACT:
SUBMITTER: Dhainaut M
PROVIDER: S-EPMC4491995 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Dhainaut Maxime M Coquerelle Caroline C Uzureau Sophie S Denoeud Julie J Acolty Valérie V Oldenhove Guillaume G Galuppo Adrien A Sparwasser Tim T Thielemans Kris K Pays Etienne E Yagita Hideo H Borst Jannie J Moser Muriel M
The EMBO journal 20150318 10
The severity and intensity of autoimmune disease in immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) patients and in scurfy mice emphasize the critical role played by thymus-derived regulatory T cells (tTregs) in maintaining peripheral immune tolerance. However, although tTregs are critical to prevent lethal autoimmunity and excessive inflammatory responses, their suppressive mechanism remains elusive. Here, we demonstrate that tTregs selectively inhibit CD27/CD70-dependent ...[more]