Ontology highlight
ABSTRACT:
SUBMITTER: Muzaki AR
PROVIDER: S-EPMC4801902 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Muzaki A R B M AR Tetlak P P Sheng J J Loh S C SC Setiagani Y A YA Poidinger M M Zolezzi F F Karjalainen K K Ruedl C C
Mucosal immunology 20150715 2
A crosstalk between commensals, gut immune cells, and colonic epithelia is required for a proper function of intestinal mucosal barrier. Here we investigated the importance of two distinct intestinal dendritic cell (DC) subsets in controlling intestinal inflammation. We show that Clec9A-diphtheria toxin receptor (DTR) mice after depletion of CD103(+)CD11b(-) DCs developed severe, low-dose dextran sodium sulfate (DSS)-induced colitis, whereas the lack of CD103(+)CD11b(+) DCs in Clec4a4-DTR mice d ...[more]