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Two-step synthesis of the immunogenic bacterial glycolipid BbGL1.

ABSTRACT: Chemical synthesis of a bacterial glycolipid BbGL1 is reported in two steps starting from per-O-TMS D-galactose. The key features are glycosyl iodide mediated beta-stereoselective glycosylation in the absence of neighboring group participation and regioselective acylation.

SUBMITTER: Kulkarni SS

PROVIDER: S-EPMC4492534 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature

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Two-step synthesis of the immunogenic bacterial glycolipid BbGL1.

Kulkarni Suvarn S SS Gervay-Hague Jacquelyn J

Organic letters 20080918 21

Chemical synthesis of a bacterial glycolipid BbGL1 is reported in two steps starting from per-O-TMS D-galactose. The key features are glycosyl iodide mediated beta-stereoselective glycosylation in the absence of neighboring group participation and regioselective acylation. ...[more]

PMID: 18798644

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