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Two-Step Synthesis of Complex Artificial Macrocyclic Compounds.

ABSTRACT: The design and synthesis of head-to-tail linked artificial macrocycles using the Ugi-reaction has been developed. This synthetic approach of just two steps is unprecedented, short, efficient and works over a wide range of medium (8-11) and macrocyclic (?12) loop sizes. The substrate scope and functional group tolerance is exceptional. Using this approach, we have synthesized 39 novel macrocycles by two or even one single synthetic operation. The properties of our macrocycles are discussed with respect to their potential to bind to biological targets that are not druggable by conventional, drug-like compounds. As an application of these artificial macrocycles we highlight potent p53-MDM2 antagonism.

SUBMITTER: Madhavachary R

PROVIDER: S-EPMC5660312 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Two-Step Synthesis of Complex Artificial Macrocyclic Compounds.

Madhavachary Rudrakshula R Abdelraheem Eman M M EMM Rossetti Arianna A Twarda-Clapa Aleksandra A Musielak Bogdan B Kurpiewska Katarzyna K Kalinowska-Tłuścik Justyna J Holak Tad A TA Dömling Alexander A

Angewandte Chemie (International ed. in English) 20170801 36

The design and synthesis of head-to-tail linked artificial macrocycles using the Ugi-reaction has been developed. This synthetic approach of just two steps is unprecedented, short, efficient and works over a wide range of medium (8-11) and macrocyclic (≥12) loop sizes. The substrate scope and functional group tolerance is exceptional. Using this approach, we have synthesized 39 novel macrocycles by two or even one single synthetic operation. The properties of our macrocycles are discussed with r ...[more]

PMID: 28691783

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