Ontology highlight
ABSTRACT:
SUBMITTER: Shen FM
PROVIDER: S-EPMC4493670 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Shen Feng-Min FM Zhu Lian L Ye Heng H Yang Yu-Jun YJ Pang Dai-Wen DW Zhang Zhi-Ling ZL
Scientific reports 20150707
Recently, single cell cloning techniques have been gradually developed benefited from their important roles in monoclonal antibody screening, tumor heterogeneity research fields, etc. In this study, we developed a high throughput device containing 1400 lateral chambers to efficiently isolate single cells and carry out long-term single cell clonal cultivation as well as tumor heterogeneity studies. Most of the isolated single cells could proliferate normally nearly as long as three weeks and hund ...[more]