Hijacked in cancer: the KMT2 (MLL) family of methyltransferases.
Ontology highlight
ABSTRACT:
SUBMITTER: Rao RC
PROVIDER: S-EPMC4493861 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Publications
Hijacked in cancer: the KMT2 (MLL) family of methyltransferases.
Nature reviews. Cancer 20150601 6
Histone-lysine N-methyltransferase 2 (KMT2) family proteins methylate lysine 4 on the histone H3 tail at important regulatory regions in the genome and thereby impart crucial functions through modulating chromatin structures and DNA accessibility. Although the human KMT2 family was initially named the mixed-lineage leukaemia (MLL) family, owing to the role of the first-found member KMT2A in this disease, recent exome-sequencing studies revealed KMT2 genes to be among the most frequently mutated ...[more]
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