Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC5125619 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Li Yanjing Y Han Jianming J Zhang Yuebin Y Cao Fang F Liu Zhijun Z Li Shuai S Wu Jian J Hu Chunyi C Wang Yan Y Shuai Jin J Chen Juan J Cao Liaoran L Li Dangsheng D Shi Pan P Tian Changlin C Zhang Jian J Dou Yali Y Li Guohui G Chen Yong Y Lei Ming M
Nature 20160217 7591
The mixed lineage leukaemia (MLL) family of proteins (including MLL1-MLL4, SET1A and SET1B) specifically methylate histone 3 Lys4, and have pivotal roles in the transcriptional regulation of genes involved in haematopoiesis and development. The methyltransferase activity of MLL1, by itself severely compromised, is stimulated by the three conserved factors WDR5, RBBP5 and ASH2L, which are shared by all MLL family complexes. However, the molecular mechanism of how these factors regulate the activi ...[more]