Temporally-patterned deep brain stimulation in a mouse model of multiple traumatic brain injury.
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ABSTRACT:
SUBMITTER: Tabansky I
PROVIDER: S-EPMC4494650 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Publications
Temporally-patterned deep brain stimulation in a mouse model of multiple traumatic brain injury.
Tabansky Inna I Quinkert Amy Wells AW Rahman Nadera N Muller Salomon Zev SZ Lofgren Jesper J Rudling Johan J Goodman Alyssa A Wang Yingping Y Pfaff Donald W DW
Behavioural brain research 20140727
We report that mice with closed-head multiple traumatic brain injury (TBI) show a decrease in the motoric aspects of generalized arousal, as measured by automated, quantitative behavioral assays. Further, we found that temporally-patterned deep brain stimulation (DBS) can increase generalized arousal and spontaneous motor activity in this mouse model of TBI. This arousal increase is input-pattern-dependent, as changing the temporal pattern of DBS can modulate its effect on motor activity. Finall ...[more]
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