Ontology highlight
ABSTRACT:
SUBMITTER: Nelson L
PROVIDER: S-EPMC4494933 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Nelson Laura L McKeen Hayley D HD Marshall Andrea A Mulrane Laoighse L Starczynski Jane J Storr Sarah J SJ Lanigan Fiona F Byrne Christopher C Arthur Ken K Hegarty Shauna S Ali Ahlam Abdunnabi AA Furlong Fiona F McCarthy Helen O HO Ellis Ian O IO Green Andrew R AR Rakha Emad E Young Leonie L Kunkler Ian I Thomas Jeremy J Jack Wilma W Cameron David D Jirström Karin K Yakkundi Anita A McClements Lana L Martin Stewart G SG Gallagher William M WM Dunn Janet J Bartlett John J O'Connor Darran D Robson Tracy T
Oncotarget 20150501 14
FK506-binding protein-like (FKBPL) has established roles as an anti-tumor protein, with a therapeutic peptide based on this protein, ALM201, shortly entering phase I/II clinical trials. Here, we evaluated FKBPL's prognostic ability in primary breast cancer tissue, represented on tissue microarrays (TMA) from 3277 women recruited into five independent retrospective studies, using immunohistochemistry (IHC). In a meta-analysis, FKBPL levels were a significant predictor of BCSS; low FKBPL levels in ...[more]