Ontology highlight
ABSTRACT:
SUBMITTER: Biondini M
PROVIDER: S-EPMC4495419 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Scientific reports 20150708
RalA and RalB proteins are key mediators of oncogenic Ras signaling in human oncogenesis. Herein we investigated the mechanistic contribution of Ral proteins to invasion of lung cancer A549 cells after induction of epithelial-mesenchymal transition (EMT) with TGFβ. We show that TGFβ-induced EMT promotes dissemination of A549 cells in a 2/3D assay, independently of proteolysis, by activating the Rho/ROCK pathway which generates actomyosin-dependent contractility forces that actively remodel the e ...[more]