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MiR-195 suppresses non-small cell lung cancer by targeting CHEK1.

ABSTRACT: MiR-195 suppresses tumor growth and is associated with better survival outcomes in several malignancies including non-small cell lung cancer (NSCLC). Our previous study showed high miR-195 plasma levels associated with favorable overall survival of non-smoking women with lung adenocarcinoma. To further elucidate role of miR-195 in NSCLC, we conducted in vitro experiment as well as clinical studies in a cohort of 299 NSCLC samples. We demonstrated that miR-195 expression was lower in tumor tissues and was associated with poor survival outcome. Overexpression of miR-195 suppressed tumor cell growth, migration and invasion. We discovered that CHEK1 was a direct target of miR-195, which decreased CHEK1 expression in lung cancer cells. High expression of CHEK1 in lung tumors was associated with poor overall survival. Our results suggest that miR-195 suppresses NSCLC and predicts lung cancer prognosis.

SUBMITTER: Liu B

PROVIDER: S-EPMC4496229 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature

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MiR-195 suppresses non-small cell lung cancer by targeting CHEK1.

Liu Ben B Qu Jinli J Xu Fangxiu F Guo Yan Y Wang Yu Y Yu Herbert H Qian Biyun B

Oncotarget 20150401 11

MiR-195 suppresses tumor growth and is associated with better survival outcomes in several malignancies including non-small cell lung cancer (NSCLC). Our previous study showed high miR-195 plasma levels associated with favorable overall survival of non-smoking women with lung adenocarcinoma. To further elucidate role of miR-195 in NSCLC, we conducted in vitro experiment as well as clinical studies in a cohort of 299 NSCLC samples. We demonstrated that miR-195 expression was lower in tumor tissue ...[more]

PMID: 25840419

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