Ontology highlight
ABSTRACT:
SUBMITTER: Zhang ZY
PROVIDER: S-EPMC4359307 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Zhang Zun-yi ZY Fu Sheng-ling SL Xu Su-qin SQ Zhou Xiao X Liu Xian-shen XS Xu Yong-jian YJ Zhao Jian-ping JP Wei Shuang S
Oncotarget 20150101 3
Ku80 is involved in DNA double-strand breaks (DSBs) repair. Ku80 is overexpressed in lung cancer tissues, yet, molecular mechanisms have not been examined. We identified that miRNA, hsa-miR-526b, is bound to the 3'-UTR of Ku80 mRNA, thus decreasing Ku80 expression in NSCLC cells. Hsa-miR-526b was downregulated in NSCLC tissues compared with corresponding non-tumorous tissues, and its expression was inversely correlated with Ku80 upregulation. Overexpression of Ku80 and downregulation of hsa-miR- ...[more]