Ontology highlight
ABSTRACT:
SUBMITTER: Olesch C
PROVIDER: S-EPMC4496355 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Olesch Catherine C Sha Weixiao W Angioni Carlo C Sha Lisa Katharina LK Açaf Elias E Patrignani Paola P Jakobsson Per-Johan PJ Radeke Heinfried H HH Grösch Sabine S Geisslinger Gerd G von Knethen Andreas A Weigert Andreas A Brüne Bernhard B
Oncotarget 20150401 12
Prostaglandin E2 (PGE2) favors multiple aspects of tumor development and immune evasion. Therefore, microsomal prostaglandin E synthase (mPGES-1/-2), is a potential target for cancer therapy. We explored whether inhibiting mPGES-1 in human and mouse models of breast cancer affects tumor-associated immunity. A new model of breast tumor spheroid killing by human PBMCs was developed. In this model, tumor killing required CD80 expression by tumor-associated phagocytes to trigger cytotoxic T cell act ...[more]