Unknown

Dataset Information

0

Molecular profiling of peripheral blood is associated with circulating tumor cells content and poor survival in metastatic castration-resistant prostate cancer.


ABSTRACT: The enumeration of circulating tumor cells (CTCs) in peripheral blood correlates with clinical outcome in castration-resistant prostate cancer (CRPC). We analyzed the molecular profiling of peripheral blood from 43 metastatic CRPC patients with known CTC content in order to identify genes that may be related to prostate cancer progression. Global gene expression analysis identified the differential expression of 282 genes between samples with ?5 CTCs vs <5 CTCs, 58.6% of which were previously described as over-expressed in prostate cancer (18.9% in primary tumors and 56.1% in metastasis). Those genes were involved in survival functions such as metabolism, signal transduction, gene expression, cell growth, death, and movement. The expression of selected genes was evaluated by quantitative RT-PCR. This analysis revealed a two-gene model (SELENBP1 and MMP9) with a high significant prognostic ability (HR 6; 95% CI 2.61 - 13.79; P<0.0001). The combination of the two-gene signature plus the CTCs count showed a higher prognostic ability than CTCs enumeration or gene expression alone (P<0.05). This study shows a gene expression profile in PBMNC associated with CTCs count and clinical outcome in metastatic CRPC, describing genes and pathways potentially associated with CRPC progression.

SUBMITTER: Marin-Aguilera M 

PROVIDER: S-EPMC4496379 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature

altmetric image

Publications

Molecular profiling of peripheral blood is associated with circulating tumor cells content and poor survival in metastatic castration-resistant prostate cancer.

Marín-Aguilera Mercedes M   Reig Òscar Ò   Lozano Juan José JJ   Jiménez Natalia N   García-Recio Susana S   Erill Nadina N   Gaba Lydia L   Tagliapietra Andrea A   Ortega Vanesa V   Carrera Gemma G   Colomer Anna A   Gascón Pedro P   Mellado Begoña B  

Oncotarget 20150401 12


The enumeration of circulating tumor cells (CTCs) in peripheral blood correlates with clinical outcome in castration-resistant prostate cancer (CRPC). We analyzed the molecular profiling of peripheral blood from 43 metastatic CRPC patients with known CTC content in order to identify genes that may be related to prostate cancer progression. Global gene expression analysis identified the differential expression of 282 genes between samples with ≥5 CTCs vs <5 CTCs, 58.6% of which were previously de  ...[more]

Similar Datasets

2015-04-30 | GSE66532 | GEO
2015-04-30 | E-GEOD-66532 | biostudies-arrayexpress
| S-EPMC8656805 | biostudies-literature
| S-EPMC8508038 | biostudies-literature
| S-EPMC6927320 | biostudies-literature
| S-EPMC4397279 | biostudies-literature
| S-EPMC5321124 | biostudies-other
| S-EPMC3980954 | biostudies-other
| S-EPMC6764911 | biostudies-literature
| S-EPMC6763249 | biostudies-literature