Ontology highlight
ABSTRACT:
SUBMITTER: Takada M
PROVIDER: S-EPMC5743019 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Cancer research 20170731 18
The centromere regulates proper chromosome segregation, and its dysfunction is implicated in chromosomal instability (CIN). However, relatively little is known about how centromere dysfunction occurs in cancer. Here, we define the consequences of phosphorylation by cyclin E1/CDK2 on a conserved Ser18 residue of centromere-associated protein CENP-A, an essential histone H3 variant that specifies centromere identity. Ser18 hyperphosphorylation in cells occurred upon loss of FBW7, a tumor suppresso ...[more]