Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC4424325 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Liu Yuan Y Lear Travis T Iannone Olivia O Shiva Sruti S Corey Catherine C Rajbhandari Shristi S Jerome Jacob J Chen Bill B BB Mallampalli Rama K RK
The Journal of biological chemistry 20150316 19
Fbxl7, a component of the Skp1·Cul1·F-box protein type ubiquitin E3 ligase, regulates mitotic cell cycle progression. Here we demonstrate that overexpression of Fbxl7 in lung epithelia decreases the protein abundance of survivin, a member of the inhibitor of apoptosis family. Fbxl7 mediates polyubiquitylation and proteasomal degradation of survivin by interacting with Glu-126 within its carboxyl-terminal α helix. Furthermore, both Lys-90 and Lys-91 within survivin serve as ubiquitin acceptor sit ...[more]