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Direct Arylation of Benzo[b]furan and Other Benzo-Fused Heterocycles.

ABSTRACT: The direct arylation of benzo[b]furan, benzo[b]thiophene, and indole has been studied by using aromatic bromides as the aryl source. The protocol employing common reagents and a Pd catalyst has led to the regioselective arylation of these heterocycles at the 2-position. A range of functional groups were tolerated, providing quick access to a variety of arylated benzo-fused heterocycles that would be accessible more elaborately using classical synthetic strategies. This is the first systematic study of the direct arylation of benzo[b]furan.

SUBMITTER: Dao-Huy T

PROVIDER: S-EPMC4502765 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature

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Direct Arylation of Benzo[b]furan and Other Benzo-Fused Heterocycles.

Dao-Huy Toan T Haider Maximilian M Glatz Fabian F Schnürch Michael M Mihovilovic Marko D MD

European journal of organic chemistry 20141117 36

The direct arylation of benzo[b]furan, benzo[b]thiophene, and indole has been studied by using aromatic bromides as the aryl source. The protocol employing common reagents and a Pd catalyst has led to the regioselective arylation of these heterocycles at the 2-position. A range of functional groups were tolerated, providing quick access to a variety of arylated benzo-fused heterocycles that would be accessible more elaborately using classical synthetic strategies. This is the first ...[more]

PMID: 26213483

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