Ontology highlight
ABSTRACT:
SUBMITTER: Salem M
PROVIDER: S-EPMC4502774 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Autophagy 20150401 4
Genetic variations in the autophagic pathway influence genetic predispositions to Crohn disease. Autophagy, the major lysosomal pathway for degrading and recycling cytoplasmic material, constitutes an important homeostatic cellular process. Of interest, single-nucleotide polymorphisms in ATG16L1 (autophagy-related 16-like 1 [S. cerevisiae]), a key component in the autophagic response to invading pathogens, have been associated with an increased risk of developing Crohn disease. The most common a ...[more]