Ontology highlight
ABSTRACT:
SUBMITTER: Hudson GM
PROVIDER: S-EPMC4505066 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20150608 29
Class IIa histone deacetylases repress transcription of target genes. However, their mechanism of action is poorly understood because they exhibit very low levels of deacetylase activity. The class IIa HDACs are associated with the SMRT/NCoR repression complexes and this may, at least in part, account for their repressive activity. However, the molecular mechanism of recruitment to co-repressor proteins has yet to be established. Here we show that a repeated peptide motif present in both SMRT an ...[more]