Ontology highlight
ABSTRACT:
SUBMITTER: Goldberg JM
PROVIDER: S-EPMC4506240 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Goldberg John M JM Fisher David E DE Demetri George D GD Neuberg Donna D Allsop Stephen A SA Fonseca Catia C Nakazaki Yukoh Y Nemer David D Raut Chandrajit P CP George Suzanne S Morgan Jeffrey A JA Wagner Andrew J AJ Freeman Gordon J GJ Ritz Jerome J Lezcano Cecilia C Mihm Martin M Canning Christine C Hodi F Stephen FS Dranoff Glenn G
Clinical cancer research : an official journal of the American Association for Cancer Research 20150324 14
<h4>Purpose</h4>Alveolar soft-part sarcoma (ASPS) and clear cell sarcoma (CCS) are rare mesenchymal malignancies driven by chromosomal translocations that activate members of the microphthalmia transcription factor (MITF) family. However, in contrast to malignant melanoma, little is known about their immunogenicity. To learn more about the host response to ASPS and CCS, we conducted a phase I clinical trial of vaccination with irradiated, autologous sarcoma cells engineered by adenoviral-mediate ...[more]