Ontology highlight
ABSTRACT:
SUBMITTER: Matsushita R
PROVIDER: S-EPMC4506384 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Matsushita R R Seki N N Chiyomaru T T Inoguchi S S Ishihara T T Goto Y Y Nishikawa R R Mataki H H Tatarano S S Itesako T T Nakagawa M M Enokida H H
British journal of cancer 20150609 2
<h4>Background</h4>Analysis of a microRNA (miRNA) expression signature of bladder cancer (BC) by deep-sequencing revealed that clustered miRNAs microRNA (miR)-451a, miR-144-3p, and miR-144-5p were significantly downregulated in BC tissues. We hypothesised that these miRNAs function as tumour suppressors in BC. The aim of this study was to investigate the functional roles of these miRNAs and their modulation of cancer networks in BC cells.<h4>Methods</h4>The functional studies of BC cells were pe ...[more]