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Preoperative neutrophil:lymphocyte and platelet:lymphocyte ratios predict endometrial cancer survival.


ABSTRACT:

Background

Variations in systemic inflammatory response biomarker levels have been associated with adverse clinical outcome in various malignancies. This study determined the prognostic significance of preoperative neutrophil:lymphocyte (NLR), platelet:lymphocyte (PLR) and monocyte:lymphocyte (MLR) ratios in endometrial cancer.

Methods

Clinicopathological and 5-year follow-up data were obtained for a retrospective series of surgically treated endometrial cancer patients (n=605). Prognostic significance was determined for overall (OS) and cancer-specific survival (CSS) using Cox proportional hazards models and Kaplan-Meier analysis. Receiver-operator characteristic and log-rank functions were used to optimise cut-offs. NLR, PLR and MLR associations with clinicopathological variables were determined using non-parametric tests.

Results

Applying cut-offs of ?2.4 (NLR), ?240 (PLR) and ?0.19 (MLR), NLR and PLR (but not MLR) had independent prognostic significance. Combining NLR and PLR scores stratified patients into low (NLR-low and PLR-low), intermediate (NLR-high or PLR-high) and high risk (NLR-high and PLR-high) groups: multivariable hazard ratio (HR) 2.51; P<0.001 (OS); HR 2.26; P<0.01 (CSS) for high vs low risk patients. Increased NLR and PLR were most strongly associated with advanced stage (P<0.001), whereas increased MLR was strongly associated with older age (P<0.001).

Conclusion

Both NLR and PLR are independent prognostic indicators for endometrial cancer, which can be combined to provide additional patient stratification.

SUBMITTER: Cummings M 

PROVIDER: S-EPMC4506386 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature

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Preoperative neutrophil:lymphocyte and platelet:lymphocyte ratios predict endometrial cancer survival.

Cummings M M   Merone L L   Keeble C C   Burland L L   Grzelinski M M   Sutton K K   Begum N N   Thacoor A A   Green B B   Sarveswaran J J   Hutson R R   Orsi N M NM  

British journal of cancer 20150616 2


<h4>Background</h4>Variations in systemic inflammatory response biomarker levels have been associated with adverse clinical outcome in various malignancies. This study determined the prognostic significance of preoperative neutrophil:lymphocyte (NLR), platelet:lymphocyte (PLR) and monocyte:lymphocyte (MLR) ratios in endometrial cancer.<h4>Methods</h4>Clinicopathological and 5-year follow-up data were obtained for a retrospective series of surgically treated endometrial cancer patients (n=605). P  ...[more]

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