Unknown

Dataset Information

0

The Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios Predict Reperfusion and Prognosis after Endovascular Treatment of Acute Ischemic Stroke.


ABSTRACT: Studies assessing the prognostic effect of inflammatory markers of blood cells on the outcomes of patients with acute ischemic stroke treated with endovascular treatment (EVT) are sparse. We evaluated whether the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) affect reperfusion status in patients receiving EVT. Using a multicenter registry database, 282 patients treated with EVT were enrolled in this study. The primary outcome measure was unsuccessful reperfusion rate after EVT defined by thrombolysis in cerebral infarction grades 0-2a. Logistic regression analysis was performed to analyze the association between NLR/PLR and unsuccessful reperfusion rate after EVT. Both NLR and PLR were higher in the unsuccessful reperfusion group than in the successful reperfusion group (p < 0.001). Multivariate analysis showed that both NLR and PLR were significantly associated with unsuccessful reperfusion (adjusted odds ratio (95% confidence interval): 1.11 (1.04-1.19), PLR: 1.004 (1.001-1.01)). The receiver operating characteristic curve showed that the predictive ability of both NLR and PLR was close to good (area under the curve (AUC) of NLR: 0.63, 95% CI (0.54-0.72), p < 0.001; AUC of PLR: 0.65, 95% CI (0.57-0.73), p < 0.001). The cutoff values of NLR and PLR were 6.2 and 103.6 for unsuccessful reperfusion, respectively. Higher NLR and PLR were associated with unsuccessful reperfusion after EVT. The combined application of both biomarkers could be useful for predicting outcomes after EVT.

SUBMITTER: Lee SH 

PROVIDER: S-EPMC8399654 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature

altmetric image

Publications

The Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios Predict Reperfusion and Prognosis after Endovascular Treatment of Acute Ischemic Stroke.

Lee Sang-Hwa SH   Jang Min Uk MU   Kim Yerim Y   Park So Young SY   Kim Chulho C   Kim Yeo Jin YJ   Sohn Jong-Hee JH  

Journal of personalized medicine 20210722 8


<h4>Background</h4>Studies assessing the prognostic effect of inflammatory markers of blood cells on the outcomes of patients with acute ischemic stroke treated with endovascular treatment (EVT) are sparse. We evaluated whether the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) affect reperfusion status in patients receiving EVT.<h4>Methods</h4>Using a multicenter registry database, 282 patients treated with EVT were enrolled in this study. The primary outcome measur  ...[more]

Similar Datasets

| S-EPMC4506386 | biostudies-literature
| S-EPMC7501491 | biostudies-literature
| S-EPMC7331861 | biostudies-literature
| S-EPMC7656697 | biostudies-literature
| S-EPMC9972818 | biostudies-literature
| S-EPMC5992181 | biostudies-literature
| S-EPMC7433160 | biostudies-literature
| S-EPMC9978711 | biostudies-literature
| S-EPMC9290168 | biostudies-literature
| S-EPMC5220440 | biostudies-other