Ontology highlight
ABSTRACT:
SUBMITTER: Wang B
PROVIDER: S-EPMC4506494 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Nature communications 20150702
The naturally occurring diazobenzofluorenes, kinamycins, fluostatins and lomaiviticins, possess highly oxygenated A-rings, via which the last forms a dimeric pharmacophore. However, neither the A-ring transformation nor the dimerization mechanisms have been explored thus far. Here we propose a unified biosynthetic logic for the three types of antibiotics and verify one key reaction via detailed genetic and enzymatic experiments. Alp1U and Lom6 from the kinamycin and lomaiviticin biosynthesis, re ...[more]