Ontology highlight
ABSTRACT:
SUBMITTER: Buratto R
PROVIDER: S-EPMC4506523 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
ChemMedChem 20140904 11
Transverse and longitudinal relaxation times (T1ρ and T1) have been widely exploited in NMR to probe the binding of ligands and putative drugs to target proteins. We have shown recently that long-lived states (LLS) can be more sensitive to ligand binding. LLS can be excited if the ligand comprises at least two coupled spins. Herein we broaden the scope of ligand screening by LLS to arbitrary ligands by covalent attachment of a functional group, which comprises a pair of coupled protons that are ...[more]