Ontology highlight
ABSTRACT:
SUBMITTER: Chen GL
PROVIDER: S-EPMC4507043 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Chen George L GL Arai Sally S Flowers Mary E D ME Otani Joanne M JM Qiu Jingxin J Cheng Ethan C EC McMillan Alex A Johnston Laura J LJ Shizuru Judith A JA Miklos David B DB
Blood 20110809 15
Stimulatory antiplatelet derived growth factor receptor α (PDGFRA) antibodies have been associated with extensive chronic graft-versus-host disease (cGVHD). We performed a phase 1 dose escalation trial of imatinib in corticosteroid-dependent/refractory cGVHD to assess the safety of imatinib and test the hypothesis that abrogation of PDGFRA signaling can ameliorate the manifestations of cGVHD. Fifteen patients were enrolled. Mean follow-up time was 56.6 weeks (range, 18-82.4 weeks). Imatinib 400 ...[more]