Dataset Information
Synthesis of Staphylococcus aureus Type 5 trisaccharide repeating unit: solving the problem of lactamization.
Ontology highlight
ABSTRACT:
SUBMITTER: Gagarinov IA
PROVIDER: S-EPMC4507426 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Publications
Synthesis of Staphylococcus aureus Type 5 trisaccharide repeating unit: solving the problem of lactamization.
Organic letters 20150206 4
The chemical synthesis of an orthogonally protected trisaccharide derived from the polysaccharide of Staphylococcus aureus Type 5, which is an attractive candidate for the development of immunotherapies, is described. The challenging α-fucosylation and β-mannosylation are addressed through the careful choice of protecting groups. Lactamization of a β-D-ManpNAcA moiety during deprotection was avoided by a late stage oxidation approach. Versatility of the trisaccharide was demonstrated by its tran ...[more]