Ontology highlight
ABSTRACT:
SUBMITTER: Shaw MH
PROVIDER: S-EPMC4508204 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20150619 25
A short entry to substituted azocanes by a Rh-catalyzed cycloaddition-fragmentation process is described. Specifically, exposure of diverse N-cyclopropylacrylamides to phosphine-ligated cationic Rh(I) catalyst systems under a CO atmosphere enables the directed generation of rhodacyclopentanone intermediates. Subsequent insertion of the alkene component is followed by fragmentation to give the heterocyclic target. Stereochemical studies show, for the first time, that alkene insertion into rhodacy ...[more]