Ontology highlight
ABSTRACT:
SUBMITTER: Lee EE
PROVIDER: S-EPMC2747361 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Organic letters 20080220 6
An enantioselective synthesis of indolizidines bearing quaternary substituted stereocenters by way of a rhodium-catalyzed [2+2+2] cycloaddition of substituted alkenyl isocyanates and terminal alkynes is described. The reaction provides lactam products using aliphatic alkynes, whereas aryl alkynes give rise to vinylogous amide products. Through modification of the phosphoramidite ligand, high levels of enantioselectivity, regioselectivity, and product selectivity are obtained for both products. ...[more]