Estimation of chronic personal exposure to airborne polycyclic aromatic hydrocarbons.

ABSTRACT: BACKGROUND:Polycyclic aromatic hydrocarbons (PAH) exposure from solid fuel burning represents an important public health issue for the majority of the global population. Yet, understanding of individual-level exposures remains limited. OBJECTIVES:To develop regionally adaptable chronic personal exposure model to pro-carcinogenic PAH (c-PAH) for the population in Kraków, Poland. METHODS:We checked the assumption of spatial uniformity in eight c-PAH using the coefficients of divergence (COD), a marker of absolute concentration differences. Upon successful validation, we developed personal exposure models for eight pro-carcinogenic PAH by integrating individual-level data with area-level meteorological or pollutant data. We checked the resulting model for accuracy and precision against home outdoor monitoring data. RESULTS:During winter, COD of 0.1 for Kraków suggest overall spatial uniformity in the ambient concentration of the eight c-PAH. The three models that we developed were associated with index of agreement approximately equal to 0.9, root mean square error < 2.6 ng/m(3), and 90th percentile of absolute difference ? 4 ng/m(3) for the predicted and the observed concentrations for eight pro-carcinogenic PAH. CONCLUSIONS:Inexpensive and logistically feasible information could be used to estimate chronic personal exposure to PAH profiles, in lieu of costly and labor-intensive personal air monitoring at wide scale. At the same time, thorough validation through direct personal monitoring and assumption checking are critical for successful model development.

SUBMITTER: Choi H 

PROVIDER: S-EPMC4508844 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature