Ontology highlight
ABSTRACT:
SUBMITTER: Jenkins DC
PROVIDER: S-EPMC4509520 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
European biophysics journal : EBJ 20090303 5
The conversion of the cellular form of the prion protein (PrP(C)) to an altered disease state, generally denoted as scrapie isoform (PrP(Sc)), appears to be a crucial molecular event in prion diseases. The details of this conformational transition are not fully understood, but it is perceived that they are associated with misfolding of PrP or its incapacity to maintain the native fold during its cell cycle. Here we present a tryptophan mutant of PrP (F198W), which has enhanced fluorescence sensi ...[more]