Ontology highlight
ABSTRACT:
SUBMITTER: Metcalf MD
PROVIDER: S-EPMC4509638 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Metcalf Matthew D MD Rosicky Andrew D AD Hassan Hazem E HE Eddington Natalie D ND Coop Andrew A Cunningham Christopher W CW Mercer Susan L SL
Bioorganic & medicinal chemistry letters 20140522 15
The efflux transporter protein P-glycoprotein (P-gp) is capable of affecting the central distribution of diverse neurotherapeutics, including opioid analgesics, through their active removal from the brain. P-gp located at the blood brain barrier has been implicated in the development of tolerance to opioids and demonstrated to be up-regulated in rats tolerant to morphine and oxycodone. We have previously examined the influence of hydrogen-bonding oxo-substitutents on the P-gp-mediated efflux of ...[more]