Ontology highlight
ABSTRACT:
SUBMITTER: Bisson C
PROVIDER: S-EPMC4509728 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Bisson Claudine C Britton K Linda KL Sedelnikova Svetlana E SE Rodgers H Fiona HF Eadsforth Thomas C TC Viner Russell C RC Hawkes Tim R TR Baker Patrick J PJ Rice David W DW
Structure (London, England : 1993) 20150618 7
Imidazoleglycerol-phosphate dehydratase (IGPD) catalyzes the Mn(II)-dependent dehydration of imidazoleglycerol phosphate (IGP) to 3-(1H-imidazol-4-yl)-2-oxopropyl dihydrogen phosphate during biosynthesis of histidine. As part of a program of herbicide design, we have determined a series of high-resolution crystal structures of an inactive mutant of IGPD2 from Arabidopsis thaliana in complex with IGP. The structures represent snapshots of the enzyme trapped at different stages of the catalytic cy ...[more]