Ontology highlight
ABSTRACT:
SUBMITTER: Babbitt SE
PROVIDER: S-EPMC4509832 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Babbitt Shalon E SE Sutherland Molly C MC San Francisco Brian B Mendez Deanna L DL Kranz Robert G RG
Trends in biochemical sciences 20150611 8
Cytochromes c (cyt c) and c1 are heme proteins that are essential for aerobic respiration. Release of cyt c from mitochondria is an important signal in apoptosis initiation. Biogenesis of c-type cytochromes involves covalent attachment of heme to two cysteines (at a conserved CXXCH sequence) in the apocytochrome. Heme attachment is catalyzed in most mitochondria by holocytochrome c synthase (HCCS), which is also necessary for the import of apocytochrome c (apocyt c). Thus, HCCS affects cellular ...[more]