Ontology highlight
ABSTRACT:
SUBMITTER: Timon-Gomez A
PROVIDER: S-EPMC5842095 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Timón-Gómez Alba A Nývltová Eva E Abriata Luciano A LA Vila Alejandro J AJ Hosler Jonathan J Barrientos Antoni A
Seminars in cell & developmental biology 20170908
Mitochondrial cytochrome c oxidase (COX) is the primary site of cellular oxygen consumption and is essential for aerobic energy generation in the form of ATP. Human COX is a copper-heme A hetero-multimeric complex formed by 3 catalytic core subunits encoded in the mitochondrial DNA and 11 subunits encoded in the nuclear genome. Investigations over the last 50 years have progressively shed light into the sophistication surrounding COX biogenesis and the regulation of this process, disclosing mult ...[more]