Ontology highlight
ABSTRACT:
SUBMITTER: Su X
PROVIDER: S-EPMC4509841 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Su Xiaodi X Yu Yingpu Y Zhong Yi Y Giannopoulou Eugenia G EG Hu Xiaoyu X Liu Hui H Cross Justin R JR Rätsch Gunnar G Rice Charles M CM Ivashkiv Lionel B LB
Nature immunology 20150629 8
Interferon-γ (IFN-γ) primes macrophages for enhanced microbial killing and inflammatory activation by Toll-like receptors (TLRs), but little is known about the regulation of cell metabolism or mRNA translation during this priming. We found that IFN-γ regulated the metabolism and mRNA translation of human macrophages by targeting the kinases mTORC1 and MNK, both of which converge on the selective regulator of translation initiation eIF4E. Physiological downregulation of mTORC1 by IFN-γ was associ ...[more]