Selective transcriptional regulation by Myc: Experimental design and computational analysis of high-throughput sequencing data.
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ABSTRACT:
SUBMITTER: Pelizzola M
PROVIDER: S-EPMC4510069 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Publications
Selective transcriptional regulation by Myc: Experimental design and computational analysis of high-throughput sequencing data.
Pelizzola Mattia M Morelli Marco J MJ Sabò Arianna A Kress Theresia R TR de Pretis Stefano S Amati Bruno B
Data in brief 20150212
The gene expression programs regulated by the Myc transcription factor were evaluated by integrated genome-wide profiling of Myc binding sites, chromatin marks and RNA expression in several biological models. Our results indicate that Myc directly drives selective transcriptional regulation, which in certain physiological conditions may indirectly lead to RNA amplification. Here, we illustrate in detail the experimental design concerning the high-throughput sequencing data associated with our st ...[more]
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