Ontology highlight
ABSTRACT:
SUBMITTER: Grebien F
PROVIDER: S-EPMC4511833 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Grebien Florian F Vedadi Masoud M Getlik Matthäus M Giambruno Roberto R Grover Amit A Avellino Roberto R Skucha Anna A Vittori Sarah S Kuznetsova Ekaterina E Smil David D Barsyte-Lovejoy Dalia D Li Fengling F Poda Gennadiy G Schapira Matthieu M Wu Hong H Dong Aiping A Senisterra Guillermo G Stukalov Alexey A Huber Kilian V M KVM Schönegger Andreas A Marcellus Richard R Bilban Martin M Bock Christoph C Brown Peter J PJ Zuber Johannes J Bennett Keiryn L KL Al-Awar Rima R Delwel Ruud R Nerlov Claus C Arrowsmith Cheryl H CH Superti-Furga Giulio G
Nature chemical biology 20150713 8
The CEBPA gene is mutated in 9% of patients with acute myeloid leukemia (AML). Selective expression of a short (30-kDa) CCAAT-enhancer binding protein-α (C/EBPα) translational isoform, termed p30, represents the most common type of CEBPA mutation in AML. The molecular mechanisms underlying p30-mediated transformation remain incompletely understood. We show that C/EBPα p30, but not the normal p42 isoform, preferentially interacts with Wdr5, a key component of SET/MLL (SET-domain/mixed-lineage leu ...[more]