Ontology highlight
ABSTRACT:
SUBMITTER: Senisterra G
PROVIDER: S-EPMC3517986 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Senisterra Guillermo G Wu Hong H Allali-Hassani Abdellah A Wasney Gregory A GA Barsyte-Lovejoy Dalia D Dombrovski Ludmila L Dong Aiping A Nguyen Kong T KT Smil David D Bolshan Yuri Y Hajian Taraneh T He Hao H Seitova Alma A Chau Irene I Li Fengling F Poda Gennadiy G Couture Jean-François JF Brown Peter J PJ Al-Awar Rima R Schapira Matthieu M Arrowsmith Cheryl H CH Vedadi Masoud M
The Biochemical journal 20130101 1
WDR5 (WD40 repeat protein 5) is an essential component of the human trithorax-like family of SET1 [Su(var)3-9 enhancer-of-zeste trithorax 1] methyltransferase complexes that carry out trimethylation of histone 3 Lys4 (H3K4me3), play key roles in development and are abnormally expressed in many cancers. In the present study, we show that the interaction between WDR5 and peptides from the catalytic domain of MLL (mixed-lineage leukaemia protein) (KMT2) can be antagonized with a small molecule. Str ...[more]