Ontology highlight
ABSTRACT:
SUBMITTER: Niu T
PROVIDER: S-EPMC4512621 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Niu Tianhua T Liu Ning N Zhao Ming M Xie Guie G Zhang Lei L Li Jian J Pei Yu-Fang YF Shen Hui H Fu Xiaoying X He Hao H Lu Shan S Chen Xiang-Ding XD Tan Li-Jun LJ Yang Tie-Lin TL Guo Yan Y Leo Paul J PJ Duncan Emma L EL Shen Jie J Guo Yan-Fang YF Nicholson Geoffrey C GC Prince Richard L RL Eisman John A JA Jones Graeme G Sambrook Philip N PN Hu Xiang X Das Partha M PM Tian Qing Q Zhu Xue-Zhen XZ Papasian Christopher J CJ Brown Matthew A MA Uitterlinden André G AG Wang Yu-Ping YP Xiang Shuanglin S Deng Hong-Wen HW
Human molecular genetics 20150504 16
MicroRNAs (miRNAs) are critical post-transcriptional regulators. Based on a previous genome-wide association (GWA) scan, we conducted a polymorphism in microRNA target sites (poly-miRTS)-centric multistage meta-analysis for lumbar spine (LS)-, total hip (HIP)- and femoral neck (FN)-bone mineral density (BMD). In stage I, 41 102 poly-miRTSs were meta-analyzed in seven cohorts with a genome-wide significance (GWS) α = 0.05/41 102 = 1.22 × 10(-6). By applying α = 5 × 10(-5) (suggestive significance ...[more]