Ontology highlight
ABSTRACT:
SUBMITTER: Gould NS
PROVIDER: S-EPMC4515171 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Gould Neal S NS Evans Perry P Martínez-Acedo Pablo P Marino Stefano M SM Gladyshev Vadim N VN Carroll Kate S KS Ischiropoulos Harry H
Chemistry & biology 20150709 7
S-Acylation, S-glutathionylation, S-nitrosylation, and S-sulfenylation are prominent, chemically distinct modifications that regulate protein function, redox sensing, and trafficking. Although the biological significance of these modifications is increasingly appreciated, their integration in the proteome remains unknown. Novel mass spectrometry-based technologies identified 2,596 predominately unique sites in 1,319 mouse liver proteins under physiological conditions. Structural analysis localiz ...[more]