Site-Specific Dual Antibody Conjugation via Engineered Cysteine and Selenocysteine Residues.
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ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC4839195 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
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Site-Specific Dual Antibody Conjugation via Engineered Cysteine and Selenocysteine Residues.
Li Xiuling X Patterson James T JT Sarkar Mohosin M Pedzisa Lee L Kodadek Thomas T Roush William R WR Rader Christoph C
Bioconjugate chemistry 20150724 11
Site-specific conjugation technologies enable the production of homogeneous antibody-drug conjugates (ADCs) with improved therapeutic indices compared to conventional ADCs. However, current site-specific conjugation methods can only attach one type of drug to a single antibody. Given the emergence of acquired resistance to current ADCs, arming single antibodies with different drugs may provide an attractive option in the development of next-generation ADCs. Here, we describe a site-specific dual ...[more]
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