Ontology highlight
ABSTRACT:
SUBMITTER: Yin LL
PROVIDER: S-EPMC4516550 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Journal of cellular and molecular medicine 20090901 9B
Cancer metastasis remains the most poorly understood process in cancer biology. It involves the degradation of extracellular matrix (ECM) proteins by a series of 'tumour-associated' proteases. Here we report the identification of a novel protease suppressor, NYD-SP8, which is located on human chromosome 19q13.2. NYD-SP8 encodes a 27 kD GPI-anchored cell surface protein, which shows structural homology to urokinase plasminogen activator receptor (uPAR). Co-immunoprecipitation experiments showed t ...[more]