Ontology highlight
ABSTRACT:
SUBMITTER: Son YO
PROVIDER: S-EPMC5732273 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Nature communications 20171215 1
The estrogen-related receptor (ERR) family of orphan nuclear receptor is composed of ERRα, ERRβ, and ERRγ, which are known to regulate various isoform-specific functions under normal and pathophysiological conditions. Here, we investigate the involvement of ERRs in the pathogenesis of osteoarthritis (OA) in mice. Among ERR family members, ERRγ is markedly upregulated in cartilage from human OA patients and various mouse models of OA. Adenovirus-mediated overexpression of ERRγ in mouse knee joint ...[more]