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Azide-rich peptides via an on-resin diazotransfer reaction.

ABSTRACT: Azide-containing amino acids are valuable building blocks in peptide chemistry, because azides are robust partners in several bioorthogonal reactions. Replacing polar amino acids with apolar, azide-containing amino acids in solid-phase peptide synthesis can be tricky, especially when multiple azide residues are to be introduced in the amino acid sequence. We present a strategy for effectively incorporating multiple azide-containing residues site-specifically.

SUBMITTER: Marine JE

PROVIDER: S-EPMC4516611 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature

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Azide-rich peptides via an on-resin diazotransfer reaction.

Marine Jeannette E JE Liang Xiaoli X Song Shuang S Rudick Jonathan G JG

Biopolymers 20150701 4

Azide-containing amino acids are valuable building blocks in peptide chemistry, because azides are robust partners in several bioorthogonal reactions. Replacing polar amino acids with apolar, azide-containing amino acids in solid-phase peptide synthesis can be tricky, especially when multiple azide residues are to be introduced in the amino acid sequence. We present a strategy for effectively incorporating multiple azide-containing residues site-specifically. ...[more]

PMID: 25753459

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