T cell development involves TRAF3IP3-mediated ERK signaling in the Golgi.
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ABSTRACT:
SUBMITTER: Zou Q
PROVIDER: S-EPMC4516800 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Publications
T cell development involves TRAF3IP3-mediated ERK signaling in the Golgi.
Zou Qiang Q Jin Jin J Xiao Yichuan Y Hu Hongbo H Zhou Xiaofei X Jie Zuliang Z Xie Xiaoping X Li James Y H JY Cheng Xuhong X Sun Shao-Cong SC
The Journal of experimental medicine 20150720 8
Generation of T lymphocytes in the thymus is guided by signal transduction from the T cell receptor (TCR), but the underlying mechanism is incompletely understood. Here we have identified a Golgi-associated factor, TRAF3-interacting protein 3 (TRAF3IP3), as a crucial mediator of thymocyte development. TRAF3IP3 deficiency in mice attenuates the generation of mature thymocytes caused by impaired thymocyte-positive selection. TRAF3IP3 mediates TCR-stimulated activation of the mitogen-activated prot ...[more]
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